A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation

A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation

Amongst the many strategies aiming at inhibiting HIV-1 infection, blocking viral entry has been recently recognized as a very promising approach. Using diverse in vitro models and a broad range of HIV-1 primary patient isolates, we report here that IND02, a type A procyanidin polyphenol extracted fr...

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Główni autorzy: Bridgette J. Connell, Sui‐Yuan Chang, Ekambaranellore Prakash, Rahima Yousfi, Viswaraman Mohan, Wilfried Posch, Doris Wilflingseder, Christiane Moog, Eiichi Kodama, Pascal Clayette, Hugues Lortat‐Jacob
Format: Artigo
Język:angielski
Wydane: 2016
Dostęp online:https://doi.org/10.1371/journal.pone.0165386
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0165386&type=printable
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https://doi.org/10.1371/journal.pone.0165386
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0165386&type=printable

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