RNF4-Dependent Oncogene Activation by Protein Stabilization
Ubiquitylation regulates signaling pathways critical for cancer development and, in many cases, targets proteins for degradation. Here, we report that ubiquitylation by RNF4 stabilizes otherwise short-lived oncogenic transcription factors, including β-catenin, Myc, c-Jun, and the Notch intracellular...
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| Principais autores: | , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Acesso em linha: | https://doi.org/10.1016/j.celrep.2016.08.024 https://www.cell.com/article/S2211124716310713/pdf |
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