FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

SOX9 is a master transcription factor that regulates development and stem cell programs. However, its potential oncogenic activity and regulatory mechanisms that control SOX9 protein stability are poorly understood. Here, we show that SOX9 is a substrate of FBW7, a tumor suppressor, and a SCF (SKP1/...

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Autori principali: Aldwin Suryo Rahmanto, Vasil Savov, Andrä Brunner, Sara Bolin, Holger Weishaupt, Alena Malyukova, Gabriela Rosén, Matko Čančer, Sonja Hutter, Anders Sundström, Daisuke Kawauchi, David Jones, Charles Spruck, Michael D. Taylor, Yoon‐Jae Cho, Stefan M. Pfister, Marcel Kool, Andrey Korshunov, Fredrik J. Swartling, Olle Sangfelt
Natura: Artigo
Lingua:inglese
Pubblicazione: 2016
Accesso online:https://doi.org/10.15252/embj.201693889
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https://doi.org/10.15252/embj.201693889

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