Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA)

Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA)

Significance 4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA), a potent antiviral with an unusually long half-life, is currently in phase I clinical trials. It inhibits reverse transcriptase (RT) through a mechanism of action different from all approved anti-HIV drugs: After incorporation in the nascent...

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Podrobná bibliografie
Hlavní autoři:	Zhe Salie, Karen A. Kirby, Eleftherios Michailidis, Bruno Marchand, Kamalendra Singh, Lisa C. Rohan, Eiichi Kodama, Hiroaki Mitsuya, Michael A. Parniak, Stefan G. Sarafianos
Médium:	Artigo
Jazyk:	angličtina
Vydáno:	2016
On-line přístup:	https://doi.org/10.1073/pnas.1605223113 https://www.pnas.org/content/pnas/113/33/9274.full.pdf
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

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