Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA)
Significance 4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA), a potent antiviral with an unusually long half-life, is currently in phase I clinical trials. It inhibits reverse transcriptase (RT) through a mechanism of action different from all approved anti-HIV drugs: After incorporation in the nascent...
Sábháilte in:
| Príomhchruthaitheoirí: | , , , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Béarla |
| Foilsithe / Cruthaithe: |
2016
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| Rochtain ar líne: | https://doi.org/10.1073/pnas.1605223113 https://www.pnas.org/content/pnas/113/33/9274.full.pdf |
| Clibeanna: |
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