Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo

Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo

Clinical options for patients harbouring advanced/recurrent uterine serous carcinoma (USC), an aggressive variant of endometrial tumour, are very limited. Next-generation sequencing (NGS) data recently demonstrated that cyclin E1 (CCNE1) gene amplification and pik3ca driver mutations are common in U...

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Hlavní autoři: Emiliano Cocco, Salvatore Lopez, Jonathan Black, Stefania Bellone, Elena Bonazzoli, Federica Predolini, Francesca Ferrari, Carlton L. Schwab, Gulden Menderes, Luca Zammataro, Natália Buza, Pei Hui, Serena Wong, Siming Zhao, Yalai Bai, David L. Rimm, Elena Ratner, Babak Litkouhi, Dan‐Arin Silasi, Masoud Azodi, Peter E. Schwartz, Alessandro D. Santin
Médium: Artigo
Jazyk:angličtina
Vydáno: 2016
On-line přístup:https://doi.org/10.1038/bjc.2016.198
https://www.nature.com/articles/bjc2016198.pdf
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https://doi.org/10.1038/bjc.2016.198
https://www.nature.com/articles/bjc2016198.pdf

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