Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo

Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo

Clinical options for patients harbouring advanced/recurrent uterine serous carcinoma (USC), an aggressive variant of endometrial tumour, are very limited. Next-generation sequencing (NGS) data recently demonstrated that cyclin E1 (CCNE1) gene amplification and pik3ca driver mutations are common in U...

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Detalhes bibliográficos
Principais autores: Emiliano Cocco, Salvatore Lopez, Jonathan Black, Stefania Bellone, Elena Bonazzoli, Federica Predolini, Francesca Ferrari, Carlton L. Schwab, Gulden Menderes, Luca Zammataro, Natália Buza, Pei Hui, Serena Wong, Siming Zhao, Yalai Bai, David L. Rimm, Elena Ratner, Babak Litkouhi, Dan‐Arin Silasi, Masoud Azodi, Peter E. Schwartz, Alessandro D. Santin
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Acesso em linha:https://doi.org/10.1038/bjc.2016.198
https://www.nature.com/articles/bjc2016198.pdf
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https://doi.org/10.1038/bjc.2016.198
https://www.nature.com/articles/bjc2016198.pdf

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