Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease
Abstract Non-alcoholic fatty liver disease (NAFLD) has become a predictive factor of death from many diseases. Farnesoid X receptor (FXR) is an ideal target for NAFLD drug development due to its crucial roles in lipid metabolism. The aim of this work is to examine the molecular mechanisms and functi...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | engelsk |
| Udgivet: |
2015
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| Online adgang: | https://doi.org/10.1038/srep17288 https://www.nature.com/articles/srep17288.pdf |
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