Inducible T-cell co-stimulator ligand (ICOSL) blockade leads to selective inhibition of anti-KLH IgG responses in subjects with systemic lupus erythematosus

Inducible T-cell co-stimulator ligand (ICOSL) blockade leads to selective inhibition of anti-KLH IgG responses in subjects with systemic lupus erythematosus

To evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single-dose and multiple-dose administration of AMG 557, a human anti-inducible T cell co-stimulator ligand (ICOSL) monoclonal antibody, in subjects with systemic lupus erythematosus (SLE). Patients with mild, s...

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Main Authors: Barbara Sullivan, Wayne Tsuji, Alan Kivitz, Joanna Peng, Gregory E. Arnold, Michael Boedigheimer, Kit Chiu, C L Green, Arunan Kaliyaperumal, C. Wang, John Ferbas, James Chung
Format: Artigo
Language:English
Published: 2016
Online Access:https://doi.org/10.1136/lupus-2016-000146
https://lupus.bmj.com/content/lupusscimed/3/1/e000146.full.pdf
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https://doi.org/10.1136/lupus-2016-000146
https://lupus.bmj.com/content/lupusscimed/3/1/e000146.full.pdf

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