Conditional deletion of <i>L1CAM</i> in human neurons impairs both axonal and dendritic arborization and action potential generation
Hundreds of L1CAM gene mutations have been shown to be associated with congenital hydrocephalus, severe intellectual disability, aphasia, and motor symptoms. How such mutations impair neuronal function, however, remains unclear. Here, we generated human embryonic stem (ES) cells carrying a condition...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2016
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| Online Access: | https://doi.org/10.1084/jem.20150951 |
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