Expression of PD-1 and Its Ligands, PD-L1 and PD-L2, in Smokers and Never Smokers with KRAS-Mutant Lung Cancer

Expression of PD-1 and Its Ligands, PD-L1 and PD-L2, in Smokers and Never Smokers with KRAS-Mutant Lung Cancer

IntroductionClinical responses to immune checkpoint blockade by anti-programmed cell death protein-1 (PD-1)/PD-L1 monoclonal antibodies in non–small-cell lung cancer (NSCLC) are associated with PD-L1 expression and smoking status. We aimed to determine the expression profile of PD-1 and its ligands,...

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Main Authors: Antonio Calles, Xiaoyun Liao, Lynette M. Sholl, Scott J. Rodig, Gordon J. Freeman, Mohit Butaney, Christine Lydon, Suzanne E. Dahlberg, F. Stephen Hodi, Geoffrey R. Oxnard, David M. Jackman, Pasi A. Jänne
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Acesso em linha:https://doi.org/10.1097/jto.0000000000000687
http://www.jto.org/article/S1556086415350966/pdf
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https://doi.org/10.1097/jto.0000000000000687
http://www.jto.org/article/S1556086415350966/pdf

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