A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy

A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy

Background Depending on the epidemiological setting, a variable proportion of leprosy patients will suffer from excessive pro-inflammatory responses, termed type-1 reactions (T1R). The LRRK2 gene encodes a multi-functional protein that has been shown to modulate pro-inflammatory responses. Variants...

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Hlavní autoři: Vinicius M. Fava, Jérémy Manry, Aurélie Cobat, Marianna Orlova, Nguyen Van Thuc, Nguyen Ngoc Ba, Vu Hong Thai, Laurent Abel, Alexandre Alcaïs, Erwin Schurr
Médium: Artigo
Jazyk:angličtina
Vydáno: 2016
On-line přístup:https://doi.org/10.1371/journal.pntd.0004412
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0004412&type=printable
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https://doi.org/10.1371/journal.pntd.0004412
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0004412&type=printable

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