Selective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency
Abstract Type 2 diabetes mellitus (T2DM) is a pervasive metabolic syndrome that is characterized by insulin resistance, hyperglycemia and dyslipidemia. As full agonists of PPARγ, thiazolidinedione (TZD) drugs elicit antidiabetic effects by targeting PPARγ but is accompanied by weight gain, fluid ret...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | engelsk |
| Udgivet: |
2015
|
| Online adgang: | https://doi.org/10.1038/srep12222 https://www.nature.com/articles/srep12222.pdf |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|