Selective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency
Abstract Type 2 diabetes mellitus (T2DM) is a pervasive metabolic syndrome that is characterized by insulin resistance, hyperglycemia and dyslipidemia. As full agonists of PPARγ, thiazolidinedione (TZD) drugs elicit antidiabetic effects by targeting PPARγ but is accompanied by weight gain, fluid ret...
Na minha lista:
| Principais autores: | , , , , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
|
| Acesso em linha: | https://doi.org/10.1038/srep12222 https://www.nature.com/articles/srep12222.pdf |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|