Conformational changes of the <i>Hs</i>DHODH N-terminal Microdomain via DEER Spectroscopy
The human enzyme dihydroorotate dehydrogenase (HsDHODH) has been studied for being a target for development of new antineoplasic and antiproliferative drugs. The synthetic peptide N-t(DH) represents the N-terminal microdomain of this enzyme, responsible for anchoring it to the inner mitochondrial me...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Acesso em linha: | https://doi.org/10.1021/acs.jpcb.5b01706 |
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