Mycobacterium tuberculosis WhiB3 Responds to Vacuolar pH-induced Changes in Mycothiol Redox Potential to Modulate Phagosomal Maturation and Virulence
The ability of Mycobacterium tuberculosis to resist intraphagosomal stresses, such as oxygen radicals and low pH, is critical for its persistence. Here, we show that a cytoplasmic redox sensor, WhiB3, and the major M. tuberculosis thiol, mycothiol (MSH), are required to resist acidic stress during i...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Englisch |
| Veröffentlicht: |
2015
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| Online-Zugang: | https://doi.org/10.1074/jbc.m115.684597 http://www.jbc.org/article/S0021925820342770/pdf |
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