Enhanced Estrogen Receptor (ER) α, ERBB2, and MAPK Signal Transduction Pathways Operate during the Adaptation of MCF-7 Cells to Long Term Estrogen Deprivation

The mechanisms involved in resistance to estrogen deprivation are of major importance for optimal patient therapy and the development of new drugs. Long term culture of MCF-7 cells in estrogen (E2)-depleted medium (long term estrogen deprivation; LTED) results in hypersensitivity to E2 coinciding wi...

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Main Authors: Lesley‐Ann Martin, Ian Farmer, Stephen Johnston, Simak Ali, Chris Marshall, Mitch Dowsett
Format: Artigo
Jezik:angleščina
Izdano: 2003
Online dostop:https://doi.org/10.1074/jbc.m305226200
http://www.jbc.org/article/S0021925820840733/pdf
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