Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation
Haspin phosphorylates histone H3 at threonine-3 (H3T3ph), providing a docking site for the Aurora B complex at centromeres. Aurora B functions to correct improper kinetochore–microtubule attachments and alert the spindle checkpoint to the presence of misaligned chromosomes. We show that Haspin inhib...
Sparad:
| Huvudupphovsmän: | , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | engelska |
| Publicerad: |
2012
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| Länkar: | https://doi.org/10.1083/jcb.201205106 http://jcb.rupress.org/content/jcb/199/2/251.full.pdf |
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