Drug-sensitive<i>FGFR2</i>mutations in endometrial carcinoma

Drug-sensitive<i>FGFR2</i>mutations in endometrial carcinoma

Oncogenic activation of tyrosine kinases is a common mechanism of carcinogenesis and, given the druggable nature of these enzymes, an attractive target for anticancer therapy. Here, we show that somatic mutations of the fibroblast growth factor receptor 2 (FGFR2) tyrosine kinase gene, FGFR2 , are pr...

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Bibliografische gegevens
Hoofdauteurs: Amit Dutt, Helga B. Salvesen, Tzu-Hsiu Chen, Alex H. Ramos, Robert C. Onofrio, Charlie Hatton, Richard Nicoletti, Wendy Winckler, Rupinder Grewal, Megan Hanna, Nicolas Wyhs, Liuda Ziaugra, Daniel J. Richter, Jone Trovik, Ingeborg B. Engelsen, Ingunn M. Stefansson, Tim Fennell, Kristian Cibulskis, Michael C. Zody, Lars A. Akslen, Stacey B. Gabriel, Kwok‐Kin Wong, William R. Sellers, Matthew Meyerson, Heidi Greulich
Formaat: Artigo
Taal:Engels
Gepubliceerd in: 2008
Online toegang:https://doi.org/10.1073/pnas.0803379105
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https://doi.org/10.1073/pnas.0803379105

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