Terminal osteoblast differentiation, mediated by runx2 and p27<i>KIP1</i>, is disrupted in osteosarcoma
The molecular basis for the inverse relationship between differentiation and tumorigenesis is unknown. The function of runx2, a master regulator of osteoblast differentiation belonging to the runt family of tumor suppressor genes, is consistently disrupted in osteosarcoma cell lines. Ectopic express...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2004
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| 在線閱讀: | https://doi.org/10.1083/jcb.200409187 https://rupress.org/jcb/article-pdf/167/5/925/1316710/jcb1675925.pdf |
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