Terminal osteoblast differentiation, mediated by runx2 and p27<i>KIP1</i>, is disrupted in osteosarcoma

Terminal osteoblast differentiation, mediated by runx2 and p27<i>KIP1</i>, is disrupted in osteosarcoma

The molecular basis for the inverse relationship between differentiation and tumorigenesis is unknown. The function of runx2, a master regulator of osteoblast differentiation belonging to the runt family of tumor suppressor genes, is consistently disrupted in osteosarcoma cell lines. Ectopic express...

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Hoofdauteurs: David M. Thomas, Sandra Johnson, Natalie A. Sims, Melanie Trivett, John Slavin, Brian P. Rubin, Paul Waring, Grant A. McArthur, Carl R. Walkley, Andrew Holloway, Dileepa Diyagama, Jonathon E. Grim, Bruce E. Clurman, David D.L. Bowtell, Jong-Seo Lee, Gabriel M. Gutierrez, Denise M. Piscopo, Shannon A. Carty, Philip W. Hinds
Formaat: Artigo
Taal:Engels
Gepubliceerd in: 2004
Online toegang:https://doi.org/10.1083/jcb.200409187
https://rupress.org/jcb/article-pdf/167/5/925/1316710/jcb1675925.pdf
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https://doi.org/10.1083/jcb.200409187
https://rupress.org/jcb/article-pdf/167/5/925/1316710/jcb1675925.pdf

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