ABCB1 Genotypes Predict Cyclosporine-Related Adverse Events and Kidney Allograft Outcome
Cyclosporine A (CsA) is a substrate of P-glycoprotein, an efflux transporter encoded by the ABCB1 gene. Compared with carriers of the wild-type gene, carriers of T allelic variants in exons 21 or 26 have reduced P-glycoprotein activity and, secondarily, increased intracellular concentration of CsA;...
Sparad:
| Huvudupphovsmän: | , , , , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | engelska |
| Publicerad: |
2009
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| Länkar: | https://doi.org/10.1681/asn.2008080819 |
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