Novel<i>KCNJ5</i>Mutations in Sporadic Aldosterone-Producing Adenoma Reduce Kir3.4 Membrane Abundance
Aldosterone-producing adenoma (APA) has been linked to mutations in the KCNJ5 gene encoding the inward-rectifying potassium (K(+)) Kir3.4 channel. These mutations abolish the K(+) selectivity of Kir3.4 and, consequently, cause sodium (Na(+)) leak, depolarized membrane potential, and nonsuppressible...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | inglés |
| Publicado: |
2014
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| Acceso en liña: | https://doi.org/10.1210/jc.2014-3009 https://academic.oup.com/jcem/article-pdf/100/1/E155/9096337/jcemE155.pdf |
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