WNK1 activates SGK1 to regulate the epithelial sodium channel
WNK (with no lysine [K]) kinases are serine-threonine protein kinases with an atypical placement of the catalytic lysine. Intronic deletions increase the expression of WNK1 in humans and cause pseudohypoaldosteronism type II, a form of hypertension. WNKs have been linked to ion carriers, but the und...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | английский |
| Опубликовано: |
2005
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| Online-ссылка: | https://doi.org/10.1073/pnas.0504422102 |
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