Heterozygous LmnadelK32 mice develop dilated cardiomyopathy through a combined pathomechanism of haploinsufficiency and peptide toxicity

Heterozygous LmnadelK32 mice develop dilated cardiomyopathy through a combined pathomechanism of haploinsufficiency and peptide toxicity

Dilated cardiomyopathy (DCM) associates left ventricular (LV) dilatation and systolic dysfunction and is a major cause of heart failure and cardiac transplantation. LMNA gene encodes lamins A/C, proteins of the nuclear envelope. LMNA mutations cause DCM with conduction and/or rhythm defects. The pat...

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Principais autores: Marie‐Elodie Cattin, A. Bertrand, Saskia Schlossarek, Marie‐Catherine Le Bihan, Søren Skov Jensen, Christiane Neuber, Claudia Crocini, Sophia Maron, Jeanne Lainé, Nathalie Mougenot, Shaïda Varnous, Yves Fromes, Arne Hansen, Thomas Eschenhagen, V. Decostre, Lucie Carrier, Gisèle Bonne
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Acesso em linha:https://doi.org/10.1093/hmg/ddt172
https://academic.oup.com/hmg/article-pdf/22/15/3152/17260382/ddt172.pdf
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Internet

https://doi.org/10.1093/hmg/ddt172
https://academic.oup.com/hmg/article-pdf/22/15/3152/17260382/ddt172.pdf

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