Mapping of the ligand-binding site on the b′ domain of human PDI: interaction with peptide ligands and the x-linker region

PDI (protein disulfide-isomerase) catalyses the formation of native disulfide bonds of secretory proteins in the endoplasmic reticulum. PDI consists of four thioredoxin-like domains, of which two contain redox-active catalytic sites (a and a'), and two do not (b and b'). The b' domain...

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Main Authors: Lee J. Byrne, Ateesh Sidhu, A. Katrine Wallis, Lloyd W. Ruddock, Robert B. Freedman, Mark J. Howard, Richard A. Williamson
格式: Artigo
语言:英语
出版: 2009
在线阅读:https://doi.org/10.1042/bj20090565
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