Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice

Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice

The Mycobacterium tuberculosis genome contains four copies of an operon called mce (mce1-4). Previously we reported that M. tuberculosis disrupted in the mce1 operon is more virulent than wild-type M. tuberculosis in mice. We generated single deletion mutants in mce3 (Deltamce3) and mce4 (Deltamce4)...

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Main Authors: Ryan H. Senaratne, Ben S. Sidders, Patrícia Carvalho de Sequeira, G. F. T. Saunders, Kathleen Y. Dunphy, Olivera Marjanovic, J. Rachel Reader, Patricia Lima, Stephen Chan, Sharon L. Kendall, Johnjoe McFadden, Lee W. Riley
Format: Artigo
Language:English
Published: 2008
Online Access:https://doi.org/10.1099/jmm.0.47454-0
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https://doi.org/10.1099/jmm.0.47454-0

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