Combined Influence of <i>LDLR</i> and <i>HMGCR</i> Sequence Variation on Lipid-Lowering Response to Simvastatin

Combined Influence of <i>LDLR</i> and <i>HMGCR</i> Sequence Variation on Lipid-Lowering Response to Simvastatin

Although statins are efficacious for lowering low-density lipoprotein cholesterol, there is wide interindividual variation in response. We tested the extent to which combined effects of common alleles of LDLR and HMGCR can contribute to this variability.Haplotypes in the LDLR 3'-untranslated re...

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Hlavní autoři: Lara M. Mangravite, Marisa W. Medina, Jinrui Cui, Sheila Pressman, Joshua D. Smith, Mark J. Rieder, Xiuqing Guo, Deborah A. Nickerson, Jerome I. Rotter, Ronald M. Krauss
Médium: Artigo
Jazyk:angličtina
Vydáno: 2010
On-line přístup:https://doi.org/10.1161/atvbaha.110.203273
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https://doi.org/10.1161/atvbaha.110.203273

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