Human CD133 <sup>+</sup> Progenitor Cells Promote the Healing of Diabetic Ischemic Ulcers by Paracrine Stimulation of Angiogenesis and Activation of Wnt Signaling

Human CD133 <sup>+</sup> Progenitor Cells Promote the Healing of Diabetic Ischemic Ulcers by Paracrine Stimulation of Angiogenesis and Activation of Wnt Signaling

We evaluated the healing potential of human fetal aorta-derived CD133 + progenitor cells and their conditioned medium (CD133 + CCM) in a new model of ischemic diabetic ulcer. Streptozotocin-induced diabetic mice underwent bilateral limb ischemia and wounding. One wound was covered with collagen cont...

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Main Authors: Lucíola S. Barcelos, Cécile Duplàa, Nicolle Kränkel, Gallia Graiani, Gloria Invernici, Rajesh Katare, Mauro Siragusa, Marco Meloni, Ilaria Campesi, Manuela Monica, Andreas Simm, Paola Campagnolo, Giuseppe Mangialardi, Lara Stevanato, Giulio Alessandri, Costanza Emanueli, Paolo Madeddu
Format: Artigo
Language:English
Published: 2009
Online Access:https://doi.org/10.1161/circresaha.108.192138
https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.108.192138
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https://doi.org/10.1161/circresaha.108.192138
https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.108.192138

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