Protein Kinase A Effects of an Expressed <i>PRKAR1A</i> Mutation Associated with Aggressive Tumors

Protein Kinase A Effects of an Expressed <i>PRKAR1A</i> Mutation Associated with Aggressive Tumors

Abstract Most PRKAR1A tumorigenic mutations lead to nonsense mRNA that is decayed; tumor formation has been associated with an increase in type II protein kinase A (PKA) subunits. The IVS6+1G&amp;gt;T PRKAR1A mutation leads to a protein lacking exon 6 sequences [R1αΔ184-236 (R1αΔ6)]. We compared...

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Main Authors: Elise Meoli, Ioannis Bossis, Laure Cazabat, Manos Mavrakis, Anélia Horvath, Sotiris Stergiopoulos, Miriam L. Shiferaw, Glawdys Fumey, Karine Perlemoine, Michael Muchow, Audrey Robinson‐White, Frank Weinberg, Maria Nesterova, Yianna Patronas, Lionel Groussin, Jérôme Bertherat, Constantine A. Stratakis
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Acesso em linha:https://doi.org/10.1158/0008-5472.can-08-0064
https://aacrjournals.org/cancerres/article-pdf/68/9/3133/2602182/3133.pdf
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https://doi.org/10.1158/0008-5472.can-08-0064
https://aacrjournals.org/cancerres/article-pdf/68/9/3133/2602182/3133.pdf

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