Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype
The bivalent hypothesis posits that genes encoding developmental regulators required for early lineage decisions are poised in stem/progenitor cells by the balance between a repressor histone modification (H3K27me3), mediated by the Polycomb Repressor Complex 2 (PRC2), and an activator modification...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2014
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| 在线阅读: | https://doi.org/10.7554/elife.04235 |
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