Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis

Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis

The importance of transforming growth factor beta (TGFβ) as an immune regulatory cytokine in atherosclerosis has been established. However, the role of TGFβ signalling in dendritic cells (DCs) and in DC-mediated T cell proliferation and differentiation in atherosclerosis is unknown. Here, we investi...

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Autori principali: Dirk Lievens, Kim L. L. Habets, Anna-Karin Robertson, Yasmina Laouar, Holger Winkels, Timo Rademakers, Linda Beckers, Erwin Wijnands, Louis Boon, Munir M. Mosaheb, Hafid Ait‐Oufella, Ziad Mallat, Richard A. Flavell, Mats Rudling, Christoph J. Binder, Norbert Gerdes, Erik A.L. Biessen, Christian Weber, Mat J.A.P. Daemen, Johan Kuiper, Esther Lutgens
Natura: Artigo
Lingua:inglese
Pubblicazione: 2012
Accesso online:https://doi.org/10.1093/eurheartj/ehs106
https://academic.oup.com/eurheartj/article-pdf/34/48/3717/17353939/ehs106.pdf
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Accesso online

https://doi.org/10.1093/eurheartj/ehs106
https://academic.oup.com/eurheartj/article-pdf/34/48/3717/17353939/ehs106.pdf

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