Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies

Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies

A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide association studies (GWAS). True complex disease-associated loci often exert modest effects, so thei...

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Principais autores: Brendan J. Keating, Sam E. Tischfield, Sarah S. Murray, Tushar Bhangale, Thomas S. Price, Joseph Glessner, Luana Galver, Jeffrey C. Barrett, Struan F.A. Grant, Deborah Farlow, Hareesh Chandrupatla, Thomas Hansen, Saad Ajmal, George Papanicolaou, Yiran Guo, Mingyao Li, Stephanie DerOhannessian, Paul I. W. de Bakker, Swneke D. Bailey, Alexandre Montpetit, Andrew C. Edmondson, Kent D. Taylor, Xiaowu Gai, Susanna S. Wang, Myriam Fornage, Tamim H. Shaikh, Per‐Henrik Groop, Michael Boehnke, Alistair S. Hall, Andrew T. Hattersley, Edward C. Frackelton, Nick Patterson, Charleston W. K. Chiang, Cecelia E. Kim, Richard R. Fabsitz, Willem H. Ouwehand, Alkes L. Price, Patricia B. Munroe, Mark J. Caulfield, Thomas A. Drake, Eric Boerwinkle, David Reich, A.S. Whitehead, Thomas P. Cappola, Nilesh J. Samani, Aldons J. Lusis, Eric E. Schadt, James G. Wilson, Wolfgang Köenig, Mark I. McCarthy, Sekar Kathiresan, Stacey B. Gabriel, Hákon Hákonarson, Sonia S. Anand, Muredach P. Reilly, James C. Engert, Deborah A. Nickerson, Daniel J. Rader, Joel N. Hirschhorn, Garret A. FitzGerald
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Acesso em linha:https://doi.org/10.1371/journal.pone.0003583
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0003583&type=printable
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https://doi.org/10.1371/journal.pone.0003583
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0003583&type=printable

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