Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells
Up to 80% of human cancers, in particular solid tumors, contain cells with abnormal chromosomal numbers, or aneuploidy, which is often linked with marked chromosomal instability. Whereas in some tumors the aneuploidy occurs by missegregation of one or a few chromosomes, aneuploidy can also arise dur...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | inglés |
| Publicado: |
2015
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| Acceso en línea: | https://doi.org/10.1080/15384101.2015.1068482 https://www.tandfonline.com/doi/pdf/10.1080/15384101.2015.1068482?needAccess=true |
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