Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

Autosomal dominant TLR3 deficiency has been identified as a genetic etiology of childhood herpes simplex virus 1 (HSV-1) encephalitis (HSE). This defect is partial, as it results in impaired, but not abolished induction of IFN-β and -λ in fibroblasts in response to TLR3 stimulation. The apparently n...

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Váldodahkkit: Yiqi Guo, Magali Audry, Michael J. Ciancanelli, Laia Alsina, Joana Azevedo, Melina Herman, Esperanza Anguiano, Vanessa Sancho‐Shimizu, Lazaro Lorenzo, Elodie Pauwels, P Philippe, Rebeca Pérez de Diego, Annabelle Cardon, Guillaume Vogt, Capucine Pïcard, Zafitsara Zo Andrianirina, Flore Rozenberg, Pierre Lebon, Sabine Plancoulaine, Marc Tardieu, V. Doireau, Emmanuelle Jouanguy, Damien Chaussabel, Frédéric Geissmann, Laurent Abel, Jean‐Laurent Casanova, Shen‐Ying Zhang
Materiálatiipa: Artigo
Giella:eaŋgalasgiella
Almmustuhtton: 2011
Liŋkkat:https://doi.org/10.1084/jem.20101568
https://rupress.org/jem/article-pdf/208/10/2083/1203449/jem_20101568.pdf
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https://doi.org/10.1084/jem.20101568
https://rupress.org/jem/article-pdf/208/10/2083/1203449/jem_20101568.pdf

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