Gain‐of‐function mutations and copy number increases of Notch2 in diffuse large B‐cell lymphoma

Gain‐of‐function mutations and copy number increases of Notch2 in diffuse large B‐cell lymphoma

Signaling through the Notch1 receptor has a pivotal role in early thymocyte development. Gain of Notch1 function results in the development of T-cell acute lymphoblastic leukemia in a number of mouse experimental models, and activating Notch1 mutations deregulate Notch1 signaling in the majority of...

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Main Authors: Suk‐young Lee, Keiki Kumano, Kumi Nakazaki, Masashi Sanada, Akihiko Matsumoto, Go Yamamoto, Yasuhito Nannya, Ritsuro Suzuki, Satoshi Ota, Yasunori Ota, Koji Izutsu, Mamiko Sakata‐Yanagimoto, Akira Hangaishi, Hideo Yagita∥, Masashi Fukayama, Masao Seto, Mineo Kurokawa, Seishi Ogawa, Shigeru Chiba
Format: Artigo
Language:English
Published: 2009
Online Access:https://doi.org/10.1111/j.1349-7006.2009.01130.x
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.2009.01130.x
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https://doi.org/10.1111/j.1349-7006.2009.01130.x
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.2009.01130.x

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