Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers
<h3>Background</h3> Genetic factors have a substantial role in determining development of rheumatoid arthritis (RA), and are likely to account for 50–60% of disease susceptibility. Genome-wide association studies have identified non-human leucocyte antigen RA susceptibility loci which as...
Αποθηκεύτηκε σε:
Κύριοι συγγραφείς: | Darren Plant, Edward Flynn, Hamdi Mbarek, Philippe Dieudé, François Cornélis, Lisbeth Ärlestig, Solbritt Rantapää‐Dahlqvist, GN Goulielmos, Dimitrios T. Boumpas, Prodromos Sidiropoulos, Julia S. Johansen, Lykke Midtbøll Ørnbjerg, Merete Lund Hetland, Lars Klareskog, Andrew Filer, Christopher D. Buckley, Karim Raza, T Witte, Reinhold E. Schmidt, Jane Worthington |
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Μορφή: | Revisão |
Γλώσσα: | Αγγλικά |
Έκδοση: |
2010
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Διαθέσιμο Online: | https://doi.org/10.1136/ard.2009.121020 https://ard.bmj.com/content/annrheumdis/69/8/1548.full.pdf |
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Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers
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PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease.
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