Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

Inflammatory hepatocellular adenomas (IHCAs) are benign liver tumors. 60% of these tumors have IL-6 signal transducer (IL6ST; gp130) mutations that activate interleukin 6 (IL-6) signaling. Here, we report that 12% of IHCA subsets lacking IL6ST mutations harbor somatic signal transducer and activator...

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Main Authors: Camilla Pilati, Mohamed Amessou, Michel Bihl, Charles Balabaud, Jeanne Tran Van Nhieu, Valérie Paradis, Jean‐Charles Nault, Tina Izard, Paulette Bioulac‐Sage, Gabrielle Couchy, Karine Poussin, Jessica Zucman‐Rossi
Format: Artigo
Language:English
Published: 2011
Online Access:https://doi.org/10.1084/jem.20110283
https://rupress.org/jem/article-pdf/208/7/1359/1206543/jem_20110283.pdf
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