Threonine 180 Is Required for G-protein-coupled Receptor Kinase 3- and β-Arrestin 2-mediated Desensitization of the μ-Opioid Receptor in Xenopus Oocytes
To determine the sites in the μ-opioid receptor (MOR) critical for agonist-dependent desensitization, we constructed and coexpressed MORs lacking potential phosphorylation sites along with G-protein activated inwardly rectifying potassium channels composed of Kir3.1 and Kir3.4 subunits in Xenopus oo...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2001
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| 在線閱讀: | https://doi.org/10.1074/jbc.m007437200 http://www.jbc.org/article/S0021925818462916/pdf |
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