Inhibition of Mammalian Target of Rapamycin Reverses Alveolar Epithelial Neoplasia Induced by Oncogenic <i>K-ras</i>
Abstract The serine/threonine kinase AKT and its downstream mediator mammalian target of rapamycin (mTOR) are activated in lung adenocarcinoma, and clinical trials are under way to test whether inhibition of mTOR is useful in treating lung cancer. Here, we report that mTOR inhibition blocked maligna...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2005
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| 在线阅读: | https://doi.org/10.1158/0008-5472.can-04-4420 https://aacrjournals.org/cancerres/article-pdf/65/8/3226/2542217/3226-3235.pdf |
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