Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors

Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors

The success in lung cancer therapy with programmed death (PD)-1 blockade suggests that immune escape mechanisms contribute to lung tumor pathogenesis. We identified a correlation between EGF receptor (EGFR) pathway activation and a signature of immunosuppression manifested by upregulation of PD-1, P...

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Main Authors: Esra A. Akbay, Shohei Koyama, Julián Carretero, Abigail Altabef, Jeremy H. Tchaicha, Camilla L. Christensen, Oliver R. Mikse, Andrew D. Cherniack, Ellen M. Beauchamp, Trevor J. Pugh, Matthew D. Wilkerson, Peter E. Fecci, Mohit Butaney, Jacob B. Reibel, Margaret Soucheray, Travis J. Cohoon, Pasi A. Jänne, Matthew Meyerson, D. Neil Hayes, Geoffrey I. Shapiro, Takeshi Shimamura, Lynette M. Sholl, Scott J. Rodig, Gordon J. Freeman, Peter S. Hammerman, Glenn Dranoff, Kwok‐Kin Wong
Format: Artigo
Language:English
Published: 2013
Online Access:https://doi.org/10.1158/2159-8290.cd-13-0310
https://cancerdiscovery.aacrjournals.org/content/candisc/3/12/1355.full.pdf
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https://doi.org/10.1158/2159-8290.cd-13-0310
https://cancerdiscovery.aacrjournals.org/content/candisc/3/12/1355.full.pdf

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