Heterozygous <i>TBK1</i> mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood

Heterozygous <i>TBK1</i> mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood

Childhood herpes simplex virus-1 (HSV-1) encephalitis (HSE) may result from single-gene inborn errors of TLR3 immunity. TLR3-dependent induction of IFN-α/β or IFN-λ is crucial for protective immunity against primary HSV-1 infection in the central nervous system (CNS). We describe here two unrelated...

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Main Authors: Melina Herman, Michael J. Ciancanelli, Yi-Hung Ou, Lazaro Lorenzo, Maja Klaudel‐Dreszler, Elodie Pauwels, Vanessa Sancho‐Shimizu, Rebeca Pérez de Diego, Avinash Abhyankar, Elisabeth Israelsson, Yiqi Guo, Annabelle Cardon, Flore Rozenberg, Pierre Lebon, Marc Tardieu, Edyta Heropolitańska–Pliszka, Damien Chaussabel, Michael A. White, Laurent Abel, Shen‐Ying Zhang, Jean‐Laurent Casanova
Format: Artigo
Language:English
Published: 2012
Online Access:https://doi.org/10.1084/jem.20111316
http://jem.rupress.org/content/jem/209/9/1567.full.pdf
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https://doi.org/10.1084/jem.20111316
http://jem.rupress.org/content/jem/209/9/1567.full.pdf

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