The Pan-Bcl-2 Inhibitor (−)-Gossypol Triggers Autophagic Cell Death in Malignant Glioma
Antiapoptotic Bcl-2 family members suppress both apoptosis and autophagy and are of major importance for therapy resistance of malignant gliomas. To target these molecules, we used BH3 mimetics and analyzed the molecular mechanisms of cell death induced thereby. Glioma cells displayed only limited s...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | engelsk |
| Udgivet: |
2010
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| Online adgang: | https://doi.org/10.1158/1541-7786.mcr-09-0562 https://aacrjournals.org/mcr/article-pdf/8/7/1002/3146634/1002.pdf |
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