Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression
Sphingosine-1-phosphate (S1P) is a bioactive lipid that regulates multicellular functions through interactions with its receptors on cell surfaces. S1P is enriched and stored in erythrocytes; however, it is not clear whether alterations in S1P are involved in the prevalent and debilitating hemolytic...
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| Главные авторы: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | английский |
| Опубликовано: |
2014
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| Online-ссылка: | https://doi.org/10.1172/jci74604 http://www.jci.org/articles/view/74604/files/pdf |
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