Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

Sphingosine-1-phosphate (S1P) is a bioactive lipid that regulates multicellular functions through interactions with its receptors on cell surfaces. S1P is enriched and stored in erythrocytes; however, it is not clear whether alterations in S1P are involved in the prevalent and debilitating hemolytic...

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Main Authors: Yujin Zhang, Vladimír Berka, Anren Song, Kaiqi Sun, Wei Wang, Weiru Zhang, Ning Chen, Chonghua Li, Qibo Zhang, Mikhail Bogdanov, Danny C. Alexander, Michael V. Milburn, Mostafa H. Ahmed, Lin Han, Modupe Idowu, Jun Zhang, Gregory J. Kato, Osheiza Abdulmalik, Wenzheng Zhang, William Dowhan, Rodney E. Kellems, Pumin Zhang, Jianping Jin, Martin K. Safo, Ah‐Lim Tsai, Harinder S. Juneja, Yang Xia
Format: Artigo
Language:English
Published: 2014
Online Access:https://doi.org/10.1172/jci74604
http://www.jci.org/articles/view/74604/files/pdf
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https://doi.org/10.1172/jci74604
http://www.jci.org/articles/view/74604/files/pdf

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