Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

Sphingosine-1-phosphate (S1P) is a bioactive lipid that regulates multicellular functions through interactions with its receptors on cell surfaces. S1P is enriched and stored in erythrocytes; however, it is not clear whether alterations in S1P are involved in the prevalent and debilitating hemolytic...

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Príomhchruthaitheoirí: Yujin Zhang, Vladimír Berka, Anren Song, Kaiqi Sun, Wei Wang, Weiru Zhang, Ning Chen, Chonghua Li, Qibo Zhang, Mikhail Bogdanov, Danny C. Alexander, Michael V. Milburn, Mostafa H. Ahmed, Lin Han, Modupe Idowu, Jun Zhang, Gregory J. Kato, Osheiza Abdulmalik, Wenzheng Zhang, William Dowhan, Rodney E. Kellems, Pumin Zhang, Jianping Jin, Martin K. Safo, Ah‐Lim Tsai, Harinder S. Juneja, Yang Xia
Formáid: Artigo
Teanga:Béarla
Foilsithe / Cruthaithe: 2014
Rochtain ar líne:https://doi.org/10.1172/jci74604
http://www.jci.org/articles/view/74604/files/pdf
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