Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in <i>LKB1</i>-Mutant Lung Cancer

Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in <i>LKB1</i>-Mutant Lung Cancer

The LKB1/STK11 tumor suppressor encodes a serine/threonine kinase, which coordinates cell growth, polarity, motility, and metabolism. In non-small cell lung carcinoma, LKB1 is somatically inactivated in 25% to 30% of cases, often concurrently with activating KRAS mutations. Here, we used an integrat...

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में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Yan Liu, Kevin Marks, Glenn S. Cowley, Julián Carretero, Qingsong Liu, Thomas J.F. Nieland, Chunxiao Xu, Travis J. Cohoon, Peng Gao, Yong Zhang, Zhao Chen, Abigail B. Altabef, Jeremy H. Tchaicha, Xiaoxu Wang, Sung Choe, Edward M. Driggers, Jianming Zhang, Sean T. Bailey, Norman E. Sharpless, D. Neil Hayes, Nirali M. Patel, Pasi A. Jänne, Nabeel Bardeesy, Jeffrey A. Engelman, Brendan D. Manning, Reuben J. Shaw, John M. Asara, Ralph Scully, Alec C. Kimmelman, Lauren A. Byers, Don L. Gibbons, Ignacio I. Wistuba, John V. Heymach, David J. Kwiatkowski, William Y. Kim, Andrew L. Kung, Nathanael S. Gray, David E. Root, Lewis C. Cantley, Kwok‐Kin Wong
स्वरूप: Artigo
भाषा:अंग्रेज़ी
प्रकाशित: 2013
ऑनलाइन पहुंच:https://doi.org/10.1158/2159-8290.cd-13-0015
https://cancerdiscovery.aacrjournals.org/content/candisc/3/8/870.full.pdf
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इंटरनेट

https://doi.org/10.1158/2159-8290.cd-13-0015
https://cancerdiscovery.aacrjournals.org/content/candisc/3/8/870.full.pdf

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