Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in <i>LKB1</i>-Mutant Lung Cancer

Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in <i>LKB1</i>-Mutant Lung Cancer

The LKB1/STK11 tumor suppressor encodes a serine/threonine kinase, which coordinates cell growth, polarity, motility, and metabolism. In non-small cell lung carcinoma, LKB1 is somatically inactivated in 25% to 30% of cases, often concurrently with activating KRAS mutations. Here, we used an integrat...

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Main Authors: Yan Liu, Kevin Marks, Glenn S. Cowley, Julián Carretero, Qingsong Liu, Thomas J.F. Nieland, Chunxiao Xu, Travis J. Cohoon, Peng Gao, Yong Zhang, Zhao Chen, Abigail B. Altabef, Jeremy H. Tchaicha, Xiaoxu Wang, Sung Choe, Edward M. Driggers, Jianming Zhang, Sean T. Bailey, Norman E. Sharpless, D. Neil Hayes, Nirali M. Patel, Pasi A. Jänne, Nabeel Bardeesy, Jeffrey A. Engelman, Brendan D. Manning, Reuben J. Shaw, John M. Asara, Ralph Scully, Alec C. Kimmelman, Lauren A. Byers, Don L. Gibbons, Ignacio I. Wistuba, John V. Heymach, David J. Kwiatkowski, William Y. Kim, Andrew L. Kung, Nathanael S. Gray, David E. Root, Lewis C. Cantley, Kwok‐Kin Wong
Format: Artigo
Language:English
Published: 2013
Online Access:https://doi.org/10.1158/2159-8290.cd-13-0015
https://cancerdiscovery.aacrjournals.org/content/candisc/3/8/870.full.pdf
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https://doi.org/10.1158/2159-8290.cd-13-0015
https://cancerdiscovery.aacrjournals.org/content/candisc/3/8/870.full.pdf

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