Novel <i>Pseudomonas aeruginosa</i> Quorum-Sensing Inhibitors Identified in an Ultra-High-Throughput Screen

The opportunistic pathogen Pseudomonas aeruginosa has two complete acyl-homoserine lactone (acyl-HSL) signaling systems, LasR-LasI and RhlR-RhlI. LasI catalyzes the synthesis of N-3-oxododecanoyl homoserine lactone (3OC12-HSL), and LasR is a transcription factor that requires 3OC12-HSL as a ligand....

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Bibliográfalaš dieđut
Váldodahkkit: Ute Müh, Martín Schuster, Roger Heim, Ashvani K. Singh, Eric R. Olson, E. Peter Greenberg
Materiálatiipa: Artigo
Giella:eaŋgalasgiella
Almmustuhtton: 2006
Liŋkkat:https://doi.org/10.1128/aac.00665-06
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