Leptin Suppression of Insulin Secretion by the Activation of ATP-Sensitive K+ Channels in Pancreatic β-Cells
In the genetic mutant mouse models ob/ob or db/db, leptin deficiency or resistance, respectively, results in severe obesity and the development of a syndrome resembling NIDDM. One of the earliest manifestations in these mutant mice is hyperinsulinemia, suggesting that leptin may normally directly su...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
1997
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| Online Access: | https://doi.org/10.2337/diab.46.6.1087 https://diabetesjournals.org/diabetes/article-pdf/46/6/1087/513065/46-6-1087.pdf |
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